ChEBI: A polyketide and carboxamide produced by a (Pseudomonas) bacterial endosymbiont of certain rove beetles (genus Paederus). Pederin is the agent responsible for the vesicant effects (linear or Paederus dermatitis) when the beetle is
crushed against the skin. It is a powerful inhibitor of protein biosynthesis and mitosis and a potent antitumour agent.
pederine and paederine, from the blister beetle Paederus fuscipes inhibits eukaryotic protein biosynthesis and mitosis, even at concentrations of 2–3 nM. 1. Carrasco, Battaner & Vazquez Meth. Enzymol. 30, 282. 2. Jiménez Trends Biochem. Sci
