Forphenicine is a bacterial metabolite that has been found in S. fulvoviridis and an inhibitor of alkaline phosphatase (IC50 = 0.036 μg/ml for the chicken intestine enzyme).1 It inhibits the growth of HL-60 leukemia cells when used at a concentration of 10 μM.2 Forphenicine (50 and 500 μg/animal) increases survival in a guinea pig model of experimental autoimmune encephalomyelitis (EAE).3
1.Aoyagi, T., Yamamoto, T., Kojiri, K., et al.Forphenicine, and inhibitor of alkaline phosphatase produced by actinomycetesJ. Antibiot. (Tokyo)31(3)244-246(1978)
2.Miura, K., Sawa, T., Takeuchi, T., et al.Effects of enzyme inhibitors in inhibiting the growth and inducing the differentiation of human promyelocytic leukemia cells, HL-60J Antibiot (Tokyo)39(5)734-735(1986)
3.Aoyagi, T., Wada, T., Nagai, M., et al.Low-molecular-weight enzyme inhibitors suppress the development of experimental allergic encephalomyelitisExperientia40(12)1405-1407(1984)
