General procedure for the synthesis of 5-bromo-2-ethylpyrimidine from 5-bromo-2-ethyl-4-pyrimidinecarboxylic acid: 5-bromo-2-ethyl-4-pyrimidinecarboxylic acid (5.6 g, 24.3 mmol) was dissolved in xylene (50 mL), and the reaction was carried out at reflux for 2 hours. After completion of the reaction, the reaction mixture was cooled and the sample was directly upsampled onto a silica gel column, eluting first with petroleum ether and then with petroleum ether solution containing 5% ethyl acetate, and the target fractions were collected to afford compound 0601-121 (1.7 g, 38% yield) as a yellow liquid.1H NMR (400 MHz, DMSO-d6) δ: 1.26 (t, J = 7.6 Hz, 3H) 2.87 (q, J = 7.6 Hz, 2H), 8.90 (s, 2H).
