鏈菌鹼
鏈菌鹼 性质
| 熔点 | 147-148° |
|---|---|
| 比旋光度 | D25 -93° (c = 1.6 in chloroform) |
| 沸点 | 659.54°C (rough estimate) |
| 密度 | 1.1852 (rough estimate) |
| 折射率 | 1.6260 (estimate) |
| 酸度系数(pKa) | 4.50±1.00(Predicted) |
鏈菌鹼 用途与合成方法
Ki: 18 μM (Bacterial RNA polymerase)
Kd: 15 μM (Bacterial RNA polymerase)
The antibiotic Streptolydigin (Stl) is a derivative of 3-acetyltetramic acid. Binding of Streptolydigin to RNA polymerase strictly depends on a noncatalytic magnesium ion which is likely chelated by the aspartate of the bridge helix of the active center.
Streptolydigin inhibits
T. thermophilus
RNA polymerase with a K
i
of 1.8 μM.
Streptolydigin (Stl) inhibits initiation, elongation, and pyrophosphorolysis by bacterial RNA polymerase. Streptolydigin interacts with three structural elements within RNAP: the Stl pocket, the bridge helix, and the trigger-loop region. The Streptolydigin streptolol moiety interacts with the Streptolydigin pocket and bridge helix, and the Streptolydigin tetramic-acid moiety interacts with the trigger-loop region.
