3'-Azido-3'-deoxythymidine 5’-Triphosphate Tetraammonium Salt, is used for the preparation of drug against human retroviruses.
AZT triphosphate (3'-Azido-3'-deoxythymidine-5'-triphosphate) is an active triphosphate metabolite of Zidovudine (AZT). It has antiretroviral activity and inhibits HIV replication.
AZT triphosphate causes mitochondrial dysfunction, increases the production of cytotoxic reactive oxygen species (ROS), and impairs the balance of the mitochondrial quality control system in H9c2 cell model established from rat embryonic myoblasts.
HIV
HBV
DNA polymerase
Reactive oxygen species (ROS)
