N-Acetyl-S-geranylgeranyl-L-cysteine

N-acetyl-S-geranylgeranyl-L-Cysteine is a synthetic substrate for the isoprenylated protein methyltransferase (also known as S-adenosylmethionine-dependent methyltransferase). Because it is able to serve as a substrate for the methyltransferase, it effectively functions as an inhibitor of methylation of endogenous isoprenylated proteins.

N-acetyl-S-geranylgeranyl-L-Cysteine is a synthetic substrate for the isoprenylated protein methyltransferase (also known as S-adenosylmethionine-dependent methyltransferase). Because it is able to serve as a substrate for the methyltransferase, it effectively functions as an inhibitor of methylation of endogenous isoprenylated proteins.

ChEBI: N-acetyl-s-geranylgeranyl-l-cysteine is a diterpenoid.

[1] CRAIG VOLKER. A single activity carboxyl methylates both farnesyl and geranylgeranyl cysteine residues[J]. FEBS Letters, 1991, 295 1: Pages 189-194. DOI: 10.1016/0014-5793(91)81415-5
[2] D PéREZ-SALA. Prenylated protein methyltransferases do not distinguish between farnesylated and geranylgeranylated substrates.[J]. Biochemical Journal, 1992, 284 ( Pt 3): 835-840. DOI: 10.1042/bj2840835