Dantrium,Norwich Eaton ,US,1974
Dantrolene acts as a skeletal muscle relaxant through inhibition of Ca2+ release through ryanodine receptor channels.
Relaxant (skeletal muscle).
ChEBI: The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin.
5-(p-Nitrophenyl)-2-furaldehyde (40.0 grams, 0.2 mol) is dissolved in
dimethylformamide. An aqueous solution of 1-aminohydantoin hydrochloride
(30.0 grams, 0.2 mol) is added. The solution is chilled and diluted with water.
The crude material is collected and recrystallized from aqueous
dimethylformamide to yield 10.0 grams (16%). MP 279°-280°C. This
compound is then converted to the sodium salt.
Dantrium (Procter & Gamble).
Crystals (in aqueous DMF).
Slightly water soluble. Dantrolene may be sensitive to heat and air .
A nitrated amine derivative. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
SYMPTOMS: When ingested, symptoms of exposure may include drowsiness, dizziness, weakness, general malaise, fatigue, diarrhea, constipation, gastrointestinal bleeding, anorexia, abdominal cramps, hepatitis, speech disturbance, seizure, headache, light-headedness, insomnia, tachycardia, phlebitis, mental depression, mental confusion, nervousness, abdominal hair growth, rash, sweating, backache, chills and fever.
Flash point data for Dantrolene are not available. Dantrolene is probably combustible.
