Benzoic acid, 4-[[4-[(Z)-[3-(2-methylphenyl)-4-oxo-2-thioxo-5-thiazolidinylidene]methyl]phenoxy]methyl]-

JHN76359, also known as Slingshot inhibitor D3, is a novel Potent Inhibitor of the Protein Phosphatase Slingshot. This compound was first reported in ChemMedChem (2015), 10(12), 1980-1987 This product has no formal name at the moment.

Slingshot inhibitor D3 is a potent, selective, reversible and competitive inhibitor of Slingshot. The IC50 value for Slingshot 1 is 3 μM and the Ki value for Slingshot 2 is 3.9 μM. Slingshot inhibitor D3 has similar inhibitory activities toward both Slingshot 1 and Slingshot 2[1].

[1] Li KS, et al. Identification of para-Substituted Benzoic Acid Derivatives as Potent Inhibitors of the Protein Phosphatase Slingshot. ChemMedChem. 2015;10(12):1980-1987. DOI:10.1002/cmdc.201500454