Panobinostat-d4 (hydrochloride) is intended for use as an internal standard for the quantification of panobinostat (Item No. 13280) by GC- or LC-MS. Panobinostat is a pan-inhibitor of histone deacetylases (HDACs; Kis = 0.6-31 nM for HDAC1-11).1 It inhibits growth in a panel of 37 human or mouse lung cancer cell lines, including small cell lung cancer (SCLC), non-small cell lung cancer (NSCLC), and mesothelioma cancer cells (IC50s = 4-175, 5-310, and 5-470 nM, respectively), but not NCI H661 mouse NSCLC cells (IC50 = >800 nM).2 Panobinostat (20 mg/kg, i.p.) induces tumor regression in BK-T and RG-1 SCLC mouse xenograft models.WARNING This product is not for human or veterinary use.
[1] HAISHAN WANG*. Discovery of (2E)-3-{2-Butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an Orally Active Histone Deacetylase Inhibitor with a Superior Preclinical Profile[J]. Journal of Medicinal Chemistry, 2011, 54 13: 4694-4720. DOI:
10.1021/jm2003552[2] M CECILIA CRISANTI. The HDAC inhibitor panobinostat (LBH589) inhibits mesothelioma and lung cancer cells in vitro and in vivo with particular efficacy for small cell lung cancer.[J]. Molecular Cancer Therapeutics, 2009: 2221-2231. DOI:
10.1158/1535-7163.mct-09-0138
