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Panobinostat

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Panobinostat Basic information
Panobinostat Chemical Properties
  • Melting point:114-117?C
  • Density 1.241±0.06 g/cm3(Predicted)
  • storage temp. -20°C Freezer, Under Inert Atmosphere
  • pka8.71±0.23(Predicted)
Safety Information
Panobinostat Usage And Synthesis
  • DescriptionPanobinostat is a potent inhibitor of all histone deacetylases (HDACs), with Ki values ranging from 0.6 to 31 nM for HDAC1-11. Through this action, it leads to acetylation of a range of cellular proteins, resulting in cell cycle arrest and apoptosis in cancer cells. It has potential applications in several different forms of cancer as well as in spinal muscular atrophy and HIV therapy.
  • Chemical PropertiesYellow Solid
  • UsesThe novel labelled histone deacetylase inhibitor, LBH589, induces expression of DNA damage response genes and apoptosis in Ph- acute lymphoblastic leukemia cells.
  • UsesThe novel histone deacetylase inhibitor, LBH589, induces expression of DNA damage response genes and apoptosis in Ph- acute lymphoblastic leukemia cells.
  • DefinitionChEBI: A hydroxamic acid obtained by formal condensation of the carboxy group of (2E)-3-[4-({[2-(2-methylindol-3-yl)ethyl]amino}methyl)phenyl]prop-2-enoic acid with the amino group of hydroxylamine. A histone deacetylase inhibitor used (as its la tate salt) in combination with bortezomib and dexamethasone for the treatment of multiple myeloma.
Panobinostat(404950-80-7)Related Product Information
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  • Company Name:Shanghai joygo pharmacetical tech., Co., Ltd. Gold
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