(R)-3-(Carbamoylmethyl)-5-methylhexanoic acid

An impurity of the anti-convulsant (S)-Pregabalin (P704790).

(R)-3-(CARBAMOYLMETHYL)-5-METHYLHEXANOIC ACID is one of the key intermediate in the synthesis of Pregabalin. It was prepared by the resolution of racemic 3-carbamoylmethyl-5-methylhexanoic acid with (R)-1-phenylethylamine in the presence of chloroform and ethanol^[1].

[1] Sripathi, S., Somesetti, N. R., Veeramalla, R., Challa, N. R., Peddi, S., Karnati, V. R. (2010). Synthesis and characterization of impurities of an anticonvulsant drug, Pregabalin. Arkivoc, 2010 1. https://doi.org/10.3998/ARK.5550190.0011.A22