(2E,6S)-7-[[1-[2-[(2-Ethylbutyl)amino]-2-oxoethyl]-1,2-dihydro-2-oxo-3-pyridinyl]amino]-6-[[(1-methyl-1H-imidazol-5-yl)carbonyl]amino]-7-oxo-2-heptenoic Acid Methyl Ester is a derivative of pyridinone which serves as transglutaminase inhibitors.
in vivo
ZED-1227 reduces the activity of intestinal TG2 induced by Polyinosinic:Polycytidylic acid (40 mg/kg) to normal control levels and subdues intestinal inflammation in mice[1].
ZED-1227 (5 mg/kg; i.g.) is able to inhibit TG2 in the small intestinal mucosa[2].
Animal Model:
BALB/c mice[2]
Dosage:
5 mg/kg
Administration:
Oral gavage
Result:
Inhibited TG2 in vivo in the small intestinal mucosa.
