(S, R, S)-AHPC-PEG4-acid is a synthetic PROTAC linker that incorporates an E3 ligase ligand with a PEG4 arm to empower PROTAC drug research & discovery. It is reactive with amine containing molecule. The hydrophilic PEG spacer increases the solubility of a compound in aqueous media.
(S,R,S)-AHPC-PEG4-acid is a synthetic PROTAC ligand that binds the E3 ligase ligand to the PEG4 arm, thereby enhancing PROTAC drug research and discovery[1].
[1] Jian Jin, et al. Compositions and methods for treating ezh2-mediated cancer. WO2018081530A1.2018-05-03.