-20°, stored under nitrogen,unstable in solution, ready to use.
solubility
DMSO: 210 mg/mL (596.12 mM)
form
Solid
pka
1.107±0.50(predicted)
color
White to light yellow
Usage And Synthesis
Uses
Sulfo-ara-F-NMN (CZ-48) is a mimetic of nicotinamide mononucleotide (NMN). Sulfo-ara-F-NMN acts selectively, activating SARM1 but inhibiting CD38 (IC50 around 10 μM). Sulfo-ara-F-NMN induces intracellular cyclic ADP-ribose (cADPR) production[1].
References
[1] Zhao ZY, et al. A Cell-Permeant Mimetic of NMN Activates SARM1 to Produce Cyclic ADP-Ribose and Induce Non-apoptotic Cell Death. iScience. 2019 May 31;15:452-466. DOI:10.1016/j.isci.2019.05.001
