2-Benzyloxy-5-bromo-pyrimidine

2-(Benzyloxy)-5-bromopyrimidine is a pharmaceutical intermediate compound that can be used in the preparation of protein tyrosine phosphatase 2 (SHP2) inhibitors.

Synthesis of 2-(Benzyloxy)-5-bromopyrimidine: At room temperature, 5-bromo-2-chloropyrimidine (3.00 g, 15.51 mmol), benzyl alcohol (1.84 g, 17.06 mmol) and DMF (10 mL) were sequentially added to the flask.  Potassium tert-butylate (2.82 g, 23.26 mmol) was added in portions.  The mixture reacted at room temperature for 2 hours.  Water was added, and the mixture was filtered to yield 2.10 g of the pure product, a yield of 51%.