4-OXO-4,5,6,7-TETRAHYDROBENZO[B]FURAN-3-CARBOXYLIC ACID

White needle crystals. Melting point 141℃.

4-Oxo-4,5,6,7-tetrahydrobenzo[b]furan-3-carboxylic acid can be used as an intermediate of Propala.

ChEBI: 4-oxo-4,5,6,7-tetrahydrobenzo[b]furan-3-carboxylic acid is a member of benzofurans.

The methanol solution of resorcinol and potassium hydroxide is used to react with hydrogen under the action of active nickel to generate potassium 3-ketocyclohex-1-enolate, which is then cyclized with ethyl bromopyruvate under alkaline conditions , and then acidified to obtain ?4-oxo-4,5,6,7-tetrahydrobenzo[b]furan-3-carboxylic acid.