H-Ala-Phe-OH

White to off-white powder

Alanylphenylalanine is a potential antitumor agent that targets DNA via metal coordination. The complex of Alanylphenylalanine and Au (III) can bind to DNA and inhibit tumor cell proliferation[1][2].

ChEBI: A dipeptide formed from L-alanyl and L-phenylalanine residues.

Alanyl dipeptides such as ala-leu, ala-lys, ala-gly, ala-pro, ala-tyr and ala-phe may be used in physicochemical studies or to evaluate dipeptide separation technologies. Alanyl dipeptides may also be used for studying cell uptake mechanisms, dipeptide metabolism or cell growth supplementation benefits.

[1] Zhang ZH, et al. An integrated lipidomics and metabolomics reveal nephroprotective effect and biochemical mechanism of Rheum officinale in chronic renal failure. Sci Rep. 2016 Feb 23;6:22151. DOI:10.1038/srep22151
[2] Koleva B B, et al. The dipeptide alanylphenylalanine (H-Ala-Phe-OH)-protonation and coordination ability with Au (III)[J]. Journal of Molecular Structure, 2007, 831(1-3): 165-173.