2-Chloro-4-hydroxyquinazoline

607-68-1

607-69-2

General procedure for the synthesis of 2-chloroquinazolin-4-one from 2,4-dichloroquinazoline: 2,4-dichloroquinazoline (0.72 g, 3.62 mmol) was dissolved in tetrahydrofuran (6 mL), followed by the addition of aqueous sodium hydroxide solution (8 mL, 1 mol/L). The reaction mixture was stirred and reacted at room temperature overnight. Upon completion of the reaction, the pH of the reaction solution was adjusted to 5-6 with acetic acid to terminate the reaction. The reaction mixture was filtered and the filtrate was concentrated to dryness under reduced pressure to give 2-chloroquinazolin-4-one (0.60 g, 91.9% yield) as a yellow solid.