胶质纤维酸性蛋白(抗体)

Anti-GFAP Antibody, Rabbit Polyclonal Rabbit A synthetic peptide corresponding to the center region of the human GFAP Human WB,IHC-P

Immunohistochemistry - Anti-GFAP antibody (ab7260)---Abcam

GFAP antibody ab7260 was used with Tissue Clearing Kit ab243298 to penetrate, stain and clear a 1 mm coronal section of mouse brain. Blue: DAPI, Green: GFAP.Learn more about tissue clearing kits, reagents, and protocols designed to make it easier to stain thick tissue sections and get more data from each valuable tissue section.To use this antibody with tissue clearing, use Tissue Clearing Kit ab243298. For 1 mm brain sections, we recommend a starting dilution of 1:1000, and also using Goat Anti-Rabbit IgG H&L AlexaFluor488(ab150077) at a dilution of 1:400.

Produced in rabbits immunized with A synthetic peptide corresponding to the center region of the human GFAP, and purified by antigen affinity chromatography.

细胞骨架由三种胞内纤维组成：微丝（肌动蛋白丝）、中间纤丝和微管。中间纤维的主要类型在特定细胞类型中特异性表达，比如：细胞角蛋白（上皮细胞）、胶质细胞中的胶质原纤维酸性蛋白 (GFAP)、结蛋白（骨骼、内脏和某些血管平滑肌细胞）、波形蛋白（间质来源细胞）以及神经丝（神经元）。GFAP 和波形纤维蛋白形成星形胶质细胞中的中间纤丝，并且调节其运动性和形状。具体而言，波形纤维蛋白纤丝在发育早期阶段存在，而 GFAP 纤丝是分化和成熟的脑星形细胞的特征。因此，GFAP 常用作源自星形细胞的颅内和椎管内肿瘤的标记物。此外，GFAP 中间纤维也存在于周围神经系统内非髓鞘形成的雪旺氏细胞中。

GFAP是胶质纤维酸性蛋白（glial fibrillary acidic protein）是星形胶质细胞活化的标志物。胶质纤维酸性蛋白。神经胶质纤维酸性蛋白(GFAP)是一种Ⅲ型中间丝状蛋白，以单体形式存在。 在人类当中发现有8种同源异构体，相对分子质量介于(40-53)×10^3。人类GFAP基因定位于17号染色体长臂2区1带上，由9个外显子和8个内含子组成。