α-ketoglutarate dehydrogenase complex is a rate-regulating enzyme in the Krebs Cycle. Dihydrolipoamide succinyltransferase is a key subunit in this complex. Reduction of DLST increases reactive oxygen species production, suggesting its role in oxidative stress. Research has shown that deficiency of DLST in mice is linked to increased oxidative stress in mitochondria, a process that may be involved in the pathogenesis of Alzheimer's disease.
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