SALVINORIN A

Salvinorin A (Item No. 11487) is an analytical reference material categorized as a diterpene. It is a hallucinogen derived from S. divinorum that has been used in the traditional spiritual practices of the Mazatec Indians and as a recreational drug. This product is intended for research and forensic applications.

Salvinorin A is a potent and selective kappa-opioid receptor agonist. Salvinorin A has been reported to be brain-penetrant and displays psychoactive properties; hallucinogen.

Salvinorin A is a hallucinogenic derived from the S. divinorum plant used in traditional spiritual practices of the Mazatec Indians and now gaining popularity as a recreational drug. Unlike other hallucinogens, which mediate their effects through serotonin 5-HT2A receptors, salvinorin A is a potent, selective κ-opioid receptor agonist (Ki = 2.4 nM; EC50 = 1.8 nM). This product is intended for forensic and research applications.In traditional medicine, the leaves are used for divination and for treatment of anemia and excretory functions.

In traditional medicine, the leaves are used for divination and for treatment of anemia and excretory functions.

ChEBI: A natural product found in Salvia divinorum.

Potent naturally occuring non-nitrogenous κ -opioid selective agonist that displays high affinity at both native (K i = 4.3 nM) and cloned (K i = 16 nM) κ -opioid receptors. Also exhibits allosteric modulation of μ -opioid receptor binding. Reported to be brain-penetrant and displays psychoactive properties.

Salvinorin A is a potent, non-nitrogenous κ opioid selective receptor agonist. Salvinorin A is isolated from Salvia divinorum. Salvinorin A displays high affinity at both native (Ki=4.3 nm) and cloned (Ki=16 nm) κ -opioid receptors. Preliminary studies suggest that Salvanorin A is chemically unique among the psychtropic drugs and does not bind to any known receptor.

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[2] WAYNE W. HARDING. Salvinicins A (I) and B (II), New Neoclerodane Diterpenes from Salvia divinorum.[J]. ChemInform, 2005, 36 47. DOI: 10.1002/chin.200547181
[3] KENJI TSUJIKAWA . Determination of salvinorin A and salvinorin B in Salvia divinorum-related products circulated in Japan[J]. Forensic science international, 2008, 180 2: Pages 105-109. DOI: 10.1016/j.forsciint.2008.07.008
[4] THOMAS A. MUNRO . Standard protecting groups create potent and selective κ opioids: Salvinorin B alkoxymethyl ethers[J]. Bioorganic & Medicinal Chemistry, 2008, 16 3: Pages 1279-1286. DOI: 10.1016/j.bmc.2007.10.067
[5] NICHOLAS J MALCOLM. Mu-opioid receptor selective superagonists produce prolonged respiratory depression.[J]. iScience, 2023, 26 7: 107121. DOI: 10.1016/j.isci.2023.107121