Benzyltriphenylphosphonium bromide pol&

95-54-5

107-95-9

29518-68-1

GENERAL PROCEDURE: The general procedure for the synthesis of 2-(1H-benzo[d]imidazol-2-yl)ethylamine from o-phenylenediamine and β-alanine was modified with reference to the method of Phillips. L-amino acids were added to a stirring mixture of 4-nitrophthalimide and aqueous hydrochloric acid (5.5 M). The reaction mixture was heated under reflux conditions for 5 hours. Upon completion of the reaction, the blue reaction mixture was cooled to room temperature and allowed to stand overnight to allow the target product, 2-(1H-benzo[d]imidazol-2-yl)ethylamine, to crystallize and precipitate as hydrochloride. Subsequently, the reaction mixture was neutralized with 1 M K2CO3 solution to release the free base and extracted with ethyl acetate. The organic phase was evaporated to dryness and finally the product was purified by recrystallization from ethanol.