One general application of trifluoroacetaldehyde is the preparation of trifluoroethylamino derivatives via reductive amination reaction. This synthesis includes the formation of the corresponding N,O-acetal intermediates followed by their reduction using NaBH4?or 2-picoline borane complex, affording the target trifluoroethylamino compounds in moderate to good yields. Another general application of trifluoroacetaldehyde is the synthesis of chiral α-substituted trifluoroethylamino compounds.
Trifluoroacetaldehyde monohydrate is used as an agricultural
chemical, a drug and therapeutic agent, a fungicide, bactericide,
and wood preservative.
Moderately toxic by ingestion,intravenous, and intraperitoneal routes. When heated todecomposition it emits very toxic fumes of F??.
