Rize,Yoshitomi,Japan,1979
A thienodiazepine derivative that possesses anxiolytic, skeletal muscle relaxant anticonvulsant, sedative properties as well as contributing to siginificant increase stage 2 NREM sleep. It binds to be
nzodiazepine site of the GABAA receptor where it acts as a full agonist resulting in enhanced GABA inhibitory effect at the GABAA receptor.
Controlled Substance.
ChEBI: Clotiazepam is an organic molecular entity.
To a solution of 10 g of 2-N-methylaminoacetamido-3-o-chlorobenzoyl-5-ethylthiophene in 50 ml of pyridine are added 20 ml of benzene and 1.9 g of
acetic acid. The resulting mixture is refluxed with stirring for 10 hours in a
flask provided with a water-removing adaptor. The reaction mixture is
concentrated, and the residue is extracted with chloroform. The chloroform
layer is washed with water and then with a sodium hydrogen carbonate
solution, then dried over magnesium sulfate. The chloroform is distilled off
under reduced pressure, and toluene is added to the residue. Thus is
precipitated white crystalline-5-o-chlorophenyl-7-ethyl-1-methyl-1,2-dihydro-
3H-thieno-[2,3-e][1,4]diazepin-2-one, MP 105°C to 106°C.
