HTH-01-091

Product NameHTH-01-091
CAS2000209-42-5
MFC26H28Cl2N4O2
MW499.43
EINECS
MOL File2000209-42-5.mol

Chemical Properties

Boiling point	679.4±55.0 °C(Predicted)
Density	1.327±0.06 g/cm3(Predicted)
pka	6.16±0.25(Predicted)
form	Solid
color	White to light yellow

Usage And Synthesis

Description

HTH-01-091 is a selective maternal embryonic leucine zipper kinase (MELK) inhibitor. HTH-01-091 provides a general framework for preclinical target validation.

Uses

HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor, with an IC50 of 10.5 nM. HTH-01-091 also inhibits PIM1/2/3, RIPK2, DYRK3, smMLCK and CLK2. HTH-01-091 can be uesd for breast cancer research[1].

IC 50

DYRK4: 41.8 nM (IC₅₀); RIPK2; PIM1: 60.6 nM (IC₅₀); mTOR: 632 nM (IC₅₀); CDK7: 1230 nM (IC₅₀); PIM2; PIM3

References

[1] Huang HT, et al. MELK is not necessary for the proliferation of basal-like breast cancer cells. Elife. 2017 Sep 19;6:e26693. DOI:10.7554/eLife.26693