IITZ-01
中文名称:IITZ-01
英文名称:IITZ-01
CAS号:1807988-47-1
分子式:C26H23FN8O
分子量:482.51
EINECS号:
Mol文件:1807988-47-1.mol
IITZ-01 性质
沸点 | 747.0±70.0 °C(Predicted) |
---|---|
密度 | 1.420±0.06 g/cm3(Predicted) |
储存条件 | under inert gas (nitrogen or Argon) at 2–8 °C |
溶解度 | DMSO:100.0(最大浓度 mg/mL);207.24(最大浓度 mM) |
酸度系数(pKa) | 11.55±0.10(Predicted) |
形态 | 固体 |
颜色 | 白色至米白色 |
IITZ-01 用途与合成方法
IITZ-01 是一个具有抗肿瘤活性的、有效的亲溶酶体的自噬抑制剂,其对 PI3Kγ 的 IC50 值为 2.62 μM。
PI3Kγ 2.62 μM (IC 50 ) |
Autophagy
|
IITZ-01 (0-2 μM, 24 h) enhances autophagosomes formation as indicated by increased expression of LC3-II levels time- and dose-dependently in triple-negative breast cancer (TNBC) cell lines (MDA-MB-231 and MDA-MB-453). IITZ-01 also demonstrates potent autophagy inhibitory activity in other breast, lung, and colon cancer cells.
Western Blot Analysis
Cell Line: | Triple-negative breast cancer (TNBC) cell lines (MDA-MB-231 and MDA-MB-453). |
Concentration: | 0-2 μM. |
Incubation Time: | 24 hours. |
Result: | Enhanced autophagosomes formation as indicated by increased expression of LC3-II levels. |
IITZ-01 (45 mg/kg, i.p. every alternate day for 4 weeks) inhibits average breast tumor growth when compared with control from third day of treatment in triple-negative breast tumor models in mice.
Animal Model: | MDA-MB-231 (TNBC)/green fluorescent protein (GFP) orthotropic breast cancer xenografts were developed in CrTac:NCr-Foxn nu BALB/c female nude mice. |
Dosage: | 45 mg/kg. |
Administration: | Intraperitoneal every alternate day for 4 weeks. |
Result: | Inhibited average breast tumor growth when compared with control from third day of treatment. |
IITZ-01 价格(试剂级)
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024-11-08 | HY-112897 | IITZ-01 | 1807988-47-1 | 5mg | 700 |
2024-11-08 | HY-112897 | IITZ-01 | 1807988-47-1 | 10mM * 1mLin DMSO | 740 |
IITZ-01供应商 更多
无锡东禾医药科技有限公司
现货
联系电话:63313187 15358055255
产品介绍:
英文名称:IITZ-01
CAS:1807988-47-1
纯度:98%
包装信息:5mg/;10mg/;25mg/;50mg/;100mg/
备注:现货
库存量:>1g
现货日期:2025/1/22 1:38:35
上海楼岚生物科技有限公司
联系电话:021-52996696,15000506266 15000506266
产品介绍:
英文名称:IITZ-01
CAS:1807988-47-1
纯度:98% HPLC
包装信息:5mg,10mg,50mg,100mg,1g,5g
上海泽涵生物医药科技有限公司
联系电话:021-61350663 13052117465
产品介绍:
英文名称:IITZ-01
CAS:1807988-47-1
纯度:98%
包装信息:1 ml/;5 ml/
上海德欣致远生物技术有限公司
联系电话:021-58088081 Q3252066219
产品介绍:
英文名称:IITZ-01
CAS:1807988-47-1
纯度:98%
包装信息:1g;5g;50g
备注:现货
上海一飞生物科技有限公司
联系电话:021-65675885 18964387627
产品介绍:
英文名称:IITZ-01
CAS:1807988-47-1
纯度:99%
包装信息:1mg;2mg;5mg
备注:试剂级