N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE

W-13 is a naphthalenesulfonamide derivative that acts as a potent antagonist of calmodulin (IC₅₀ = 22 μM) and is widely used to investigate Ca²⁺/calmodulin-regulated enzyme activities.

Beige Solid

W-13 is a naphthalenesulfonamide derivative that acts as a potent antagonist of calmodulin (IC50 = 22 μM) and is widely used to investigate Ca2+/calmodulin-regulated enzyme activities.

Calmodulin antagonist that binds to calmodulin and inhibits calcium-ion-calmodulin- regulated activities, including phosphodiesterase activation and myosin light chain kinase127, it is widely used to investigate Ca2+/calmodulin-regulated enzyme activities.

ChEBI: N-(4-aminobutyl)-5-chloronaphthalene-2-sulfonamide hydrochloride is a hydrochloride salt prepared from equimolar amounts of N-(4-aminobutyl)-5-chloronaphthalene-2-sulfonamide and hydrogen chloride. It contains a N-(4-aminobutyl)-5-chloronaphthalene-2-sulfonamide(1+).

Calmodulin antagonist (inhibits calmodulin activated PDE activity with an IC 50 of 68 μ M). Inhibits growth of tamoxifen-resistant breast cancer cells.

W-13 has also been shown to inhibit the transcytosis of IgA, recycling of transferrin and overall alter the endocytic pathway in Madin-Darby canine kidney cells.

Store at RT

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[2] F. TEBAR. Calmodulin regulates intracellular trafficking of epidermal growth factor receptor and the MAPK signaling pathway.[J]. Molecular Biology of the Cell, 2002, 13 6 1: 2057-2068. DOI: 10.1091/mbc.01-12-0571
[3] PARIJAT SENGUPTA. Membrane-permeable calmodulin inhibitors (e.g. W-7/W-13) bind to membranes, changing the electrostatic surface potential: dual effect of W-13 on epidermal growth factor receptor activation.[J]. The Journal of Biological Chemistry, 2007, 282 11: 8474-8486. DOI: 10.1074/jbc.m607211200