C-176 (750/375 nmol C-176 per mouse in 200 μL corn oil) significantly reduces the CMA-mediated induction of serum levels of type I IFNs and IL-6., without significant toxicity[1].
C-176 results in a significant reduction in serum levels of type I IFNs and in a strong suppression of inflammatory parameters in the heart, with no evident signs of overt toxicity Trex1 / mice[1].
C-176 demonstrates marked amelioration of various signs of systemic inflammation in Trex1 / mice[1].
| Animal Model: | WT type mice. |
| Dosage: | 750/375 nmol C-176 per mouse in 200 μL corn oil (~1.34/0.67 mg/mL). |
| Administration: | Intraperitoneally, once. |
| Result: | Significantly reduced Serum levels of type I IFNs and IL-6. |
