Bisucaberin is a natural siderophore, is a DNA synthesis inhibitor. Bisucaberin shows cytostasis for tumor cells. Bisucaberin sensitizes tumor cells to macrophage-mediated cytolysis[1].
Definition
ChEBI: 1,12-Dihydroxy-1,6,12,17-tetraazacyclodocosane-2,5,13,16-tetrone is a keratan 6'-sulfate and an azamacrocycle.
References
[1] T Kameyama, et al. Bisucaberin, a new siderophore, sensitizing tumor cells to macrophage-mediated cytolysis. I. Taxonomy of the producing organism, isolation and biological properties. J Antibiot (Tokyo). 1987 Dec;40(12):1664-70. DOI:10.7164/antibiotics.40.1664
