N-(4-[[(2-Hydroxyethyl)amino]sulfonyl]phenyl)acetamide

p18SMI-21 is a novel INK4C inhibitor that specifically blocks the biological activity of p18 protein. p18SMI-21 exerts its anti-gastric acid effect through direct contact, and the intensity of this effect varies with the dose. p18SMI-21 can significantly reduce the proteolytic activity of pepsin under certain conditions. The inhibitory effect of p18SMI-21 is best achieved in direct contact with the substrate. If it contacts the substrate first, the inhibitory effect will be lost[1].

[1] [Biochemical studies on camomile components/III. In vitro studies about the antipeptic activity of (--)-alpha-bisabolol (author's transl)] PMID:21