Neurotensin (8-13) is an active fragment of Neurotensin. Neurotensin(8-13) results in a decrease in cell-surface NT1 receptors (NTR1) density.
Neurotensin (8-13) is the active fragment of neurotensin, Neurotensin (8-13) reduces cell surface NT1 receptor (NTR1) density.
Receptor internalization induced by Neurotensin(8-13) results in a decrease in cell-surface NT1 receptors (NTR1) density. The receptor downregulation in response to high extracellular concentrations of the peptide has been described for Neurotensin (NT ) in HT-29 cells and in rat primary cultured neurons. Reappearance of the receptors on the cell surface is also different.
[1] García-Garayoa E, et al. Preclinical evaluation of a new, stabilized neurotensin(8--13) pseudopeptide radiolabeled with (99m)tc. J Nucl Med. 2002 Mar;43(3):374-83. PMID:11884498
