m-PEG5-Ms

Product Namem-PEG5-Ms
CAS130955-37-2
MFC10H22O7S
MW286.34
EINECS
MOL File130955-37-2.mol

Chemical Properties

storage temp.	Storage temp. 2-8°C
form	Liquid
color	Colorless to light yellow

Usage And Synthesis

Description

m-PEG5-Ms is a PEG linker containing a mesyl group. The mesyl group is a good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases solubility in aqueous media.

Uses

m-PEG4-MS is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG4-MS is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

Biological Activity

m-PEG4-Ms is a PROTAC bridge and belongs to the PEG class. m-PEG4-Ms can be used to synthesize a series of PROTAC molecules. It is a cleavable ADC bridge for the synthesis of antibody drug conjugates (ADCs).

target

IC 50

Cleavable Linker; PEGs

References

[1] Sanxing Sun, et al. Triazolotriazine derivatives as a2a receptor antagonists. WO2020002969A1.