Cholesterol-d7

Product NameCholesterol-d7
CAS83199-47-7
MFC27H46O
MW386.66
EINECS
MOL File83199-47-7.mol

Chemical Properties

Melting point	141-143°C
storage temp.	Refrigerator
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly, Heated)
form	Solid
color	White to Off-White
InChIKey	HVYWMOMLDIMFJA-IFAPJKRJSA-N
SMILES	[H][C@@]12[C@]([C@](CC[C@H](O)C3)(C)C3=CC2)([H])CC[C@@]4(C)[C@@]1([H])CC[C@]4([H])[C@]([H])(C)CCCC([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H]
CAS Number Unlabeled	57-88-5

Safety Information

WGK Germany	WGK 1
Storage Class	11 - Combustible Solids

Usage And Synthesis

Description

Cholesterol-d₇ is intended for use as an internal standard for the quantification of cholesterol by GC- or LC-MS. Cholesterol is a major sterol produced in mammalian cells that is required for cell viability and proliferation. It is a component of mammalian cell membranes that interacts with membrane phospholipids, sphingolipids, and proteins to influence their behavior. Cholesterol is a precursor of steroid hormones, bile acids, and the active form of vitamin D. Impaired cholesterol homeostasis is related to development of various diseases including fatty liver, diabetes, gallstones, dyslipidemia, atherosclerosis, heart attack, and stroke.

Chemical Properties

White to Off-White Solid

Uses

Cholesterol-d7 is a labelled Cholesterol (C432501). Cholesterol-d7 is the principal sterol of the higher animals. Cholesterol-d7 was found in all body tissues, especial in the brain, spinal cord, and in animal fats or oils. Cholesterol-d7 is the main constituent of gallstones. Cholesterol-d7 can be used as a practical tracer for studies of cholesterol metabolism in humans.

Uses

Labelled Cholesterol (C432501). Cholesterol is the principal sterol of the higher animals. Cholesterol was found in all body tissues, especial in the brain, spinal cord, and in animal fats or oils. Cholesterol is the main constituent of gallstones.

Uses

Labelled Cholesterol can be used as a practical tracer for studies of cholesterol metabolism in humans

Definition

ChEBI: Cholesterol_d7 is a cholestanoid.

References

[1] HENNA OHVO-REKIL. Cholesterol interactions with phospholipids in membranes[J]. Progress in lipid research, 2002, 41 1: Pages 66-97. DOI: 10.1016/s0163-7827(01)00020-0
[2] RUMIANA TENCHOV. Lipid Nanoparticles─From Liposomes to mRNA Vaccine Delivery, a Landscape of Research Diversity and Advancement[J]. ACS Nano, 2021, 15 11: 16982-17015. DOI: 10.1021/acsnano.1c04996
[3] YOSHIHIDE YAMANASHI Hiroshi S Tappei Takada. Associations between Lifestyle-Related Diseases and Transporters Involved in Intestinal Absorption and Biliary Excretion of Cholesterol.[J]. Biological & pharmaceutical bulletin, 2018, 41 1: 1-10. DOI: 10.1248/bpb.b17-00690

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