Pyrrolo[1,2-b]pyridazine-3-carbonitrile has an inhibitory effect on poly(ADP-ribose) polymerase (PARP) and exhibits good biological activity both in vivo and in vitro. Therefore, Used as a PARP inhibitor in pharmaceutical compositions to prevent and/or treat PARP-related diseases such as tumors, ischemic diseases, and neurodegenerative diseases.