Ethyl 6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate is also referred to as 3-ethoxycarbonyl-6,7,8-trifluoro-1,4-hydro-4-oxoquinoline.
Ethyl 6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate is also referred to as 3-ethoxycarbonyl-6,7,8-trifluoro-1,4-hydro-4-oxoquinoline.
General procedure for the synthesis of ethyl 6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate from diethyl 2-[[(2,3,4-trifluorophenyl)amino]methylene]malonate: Compound 2 (5.30 g, 16.70 mmol) was dissolved in diphenyl ether (35 mL), and the reaction was carried out at reflux for 8 hr at 250 °C. After completion of the reaction, the reaction mixture was cooled and the precipitate precipitated was collected by filtration. The precipitate was washed with hexane and subsequently recrystallized with ethanol to give the target product 3 as a white solid.
[1] Synthetic Communications, 2009, vol. 39, # 24, p. 4375 - 4383
[2] Tetrahedron, 2007, vol. 63, # 9, p. 2093 - 2097
[3] European Journal of Medicinal Chemistry, 2011, vol. 46, # 4, p. 1232 - 1244
[4] Tetrahedron, 1992, vol. 48, # 29, p. 6135 - 6150
[5] Magnetic Resonance in Chemistry, 1996, vol. 34, # 11, p. 972 - 978
![[[(2,3,4-Trifluorophenyl)amino]methylene]propanedioic acid diethyl ester](/CAS/GIF/100501-60-8.gif)
