ChemicalBook Product Catalog Biochemical Engineering Biochemical Reagents Agonist Inhibitors evobrutinib

evobrutinib

Chemical Properties

Melting point	173 - 174oC
Boiling point	683.4±55.0 °C(Predicted)
Density	1.227±0.06 g/cm3(Predicted)
storage temp.	Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility	DMSO (Slightly), Methanol (Slightly)
pka	5.29±0.10(Predicted)
form	Solid
color	White to Off-White
Stability	Hygroscopic

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Animal Model:	Female Lewis rats with semi-established type II collagen arthritis^[1].
Dosage:	0.3, 1, 3, 10, or 30 mg/kg.
Administration:	Oral gavage once daily for 11 days (days 6-16).
Result:	Reduced ankle histopathology scores in a dose-dependent manner, compared to vehicle.