9ALPHA, 11, 15S-TRIHYDROXY-THROMBA-5Z, 13E, 17Z-TRIEN-1-OIC ACID

Product Name9ALPHA, 11, 15S-TRIHYDROXY-THROMBA-5Z, 13E, 17Z-TRIEN-1-OIC ACID
CAS71953-80-5
MFC20H32O6
MW368.46
EINECS
MOL File71953-80-5.mol

Chemical Properties

solubility

DMF: >50 mg/ml (from TXB2); DMSO: >25 mg/ml (from TXB2); Ethanol: >100 mg/ml (from TXB2); PBS pH 7.2: >100 μg/ml (from TXB2)

Usage And Synthesis

Description

Thromboxane B₃ (TXB₃) is the stable hydrolysis product of TXA₃ synthesized from eicosapentaenoic acid (EPA; ) by COX and thromboxane synthase. It is biosynthesized in various tissues such as seminal vesicles, lung, PMNL, and ocular tissues.

Uses

Thromboxane B3 (TXB3) is the stable hydrolysis product of TXA3 synthesized fromeicosapentaenoic acid (EPA; ) by COX and thromboxane synthase. It is biosynthesized in various tissues such as seminal vesicles, lung, PMNL, and ocular tissues.[Cayman Chemical]

Definition

ChEBI: A member of the class of thromboxanes B that is (5Z,13E,17Z)-thromboxa-5,13,17-trien-1-oic acid substituted by hydroxy groups at positions 9, 11 and 15.

References

[1] P S KULKARNI B D S P L Kaufman. Eicosapentaenoic acid metabolism in cynomolgus and rhesus conjunctiva and eyelid.[J]. Journal of ocular pharmacology, 1987, 3 4: 349-356. DOI: 10.1089/jop.1987.3.349
[2] PRASAD S. KULKARNI B. D S. Eicosapentaenoic acid metabolism in human and rabbit anterior uvea[J]. Prostaglandins, 1986, 31 6: Pages 1159-1164. DOI: 10.1016/0090-6980(86)90217-0