4,4'-Di-O-methylellagic acid

4,4'-di-O-methylellagic acid is the most effective compound in the inhibition of colon cancer cell proliferation.

4,4'-Di-O-methylellagic acid (4,4'-DiOMEA; Nasutin C) can be isolated from the Australian termites. 4,4'-Di-O-methylellagic acid is blue-fluorescent under ultra-violet light[1]. 4,4'-Di-O-methylellagic acid inhibits colon cancer cell proliferation via the wnt signal pathway[2].

Wnt/β-catenin

[1] B. P. MOORE, et al. Coumarin-like Substances from Australian Termites. Nature. 1962.
[2] Ana Ramírez de Molina, et al. The ellagic acid derivative 4,4'-di-O-methylellagic acid efficiently inhibits colon cancer cell growth through a mechanism involving WNT16. J Pharmacol Exp Ther. 2015, 353, 2. DOI:10.1124/jpet.114.221796