Bis-PEG10-acid

Product NameBis-PEG10-acid
CAS1268488-70-5
MFC22H42O13
MW514.56
EINECS
MOL File1268488-70-5.mol

Chemical Properties

Boiling point	630.0±55.0 °C(Predicted)
Density	1.174±0.06 g/cm3(Predicted)
storage temp.	2-8°C
pka	3.97±0.10(Predicted)
form	Solid
color	White to off-white

Usage And Synthesis

Description

Bis-PEG9-acid is a PEG linker containing two terminal carboxylic acid groups. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acids can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Uses

Bis-??PEG9-??acid is used in the preparation of plasma-stable dimeric inhibitors of PSD-95-NMDA receptor interaction.

Biological Activity

Bis-PEG10-acid is a PROTAC linker belonging to the PEG class. It can be used to synthesize a series of PROTAC molecules. It is a cleavable ADC linker for the synthesis of antibody-drug conjugates (ADCs).

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