CellHunt Orange CMTMR [5-(6)-(((4-ChloroMethyl)Benzoyl)AMino)TetraMethylrhodaMine]

CytoTrace? Orange CMTMR is a rhodamine-based, cell-permeant, vital fluorescent dye that is retained by cells for prolonged periods (>72 hours) and is passed to daughter cells. Cells loaded with long-lasting dyes, including CMTMR, are used to follow cell trafficking and cell-to-cell interactions in vivo.^1,2,3 They have also been used to estimate the growth of implanted tumor spheroids.⁴ CytoTrace? Orange CMTMR displays excitation/emission maxima of 541/565 nm, respectively.

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2. Buehler, C., Dong, C.Y., So, P.T.C., et al. Time-resolved polarization imaging by pump-probe (stimulated emission) fluorescence microscopy Biophys J. 79(1),536-549(2000).
3. Sato, K., Imai, Y., and Irimura, T. Contribution of dermal macrophage trafficking in the sensitization phase of contact hypersensitivity J. Immunol. 161(12),6835-6844(1998).
4. Borgstr?m, P., Hillan, K.J., Sriramarao, P., et al. Complete inhibition of angiogenesis and growth of microtumors by anti-vascular endothelial growth factor neutralizing antibody: Novel concepts of angiostatic therapy from intravital videomicroscopy Cancer Res. 56(17),4032-4039(1996).