CellHunt Orange CMTMR [5-(6)-(((4-ChloroMethyl)Benzoyl)AMino)TetraMethylrhodaMine]

Description

CytoTrace? Orange CMTMR is a rhodamine-based, cell-permeant, vital fluorescent dye that is retained by cells for prolonged periods (>72 hours) and is passed to daughter cells. Cells loaded with long-lasting dyes, including CMTMR, are used to follow cell trafficking and cell-to-cell interactions in vivo.^1,2,3 They have also been used to estimate the growth of implanted tumor spheroids.⁴ CytoTrace? Orange CMTMR displays excitation/emission maxima of 541/565 nm, respectively.

References

1. Brooks, A.E.S., Parsamand, T., Kelly, R.W., et al. An improved quantitative method to assess adhesive properties of Trichomonas vaginalis to host vaginal ectocervical cells using flow cytometry J. Microbiol. Methods 92(1),73-78(2013).
2. Buehler, C., Dong, C.Y., So, P.T.C., et al. Time-resolved polarization imaging by pump-probe (stimulated emission) fluorescence microscopy Biophys J. 79(1),536-549(2000).
3. Sato, K., Imai, Y., and Irimura, T. Contribution of dermal macrophage trafficking in the sensitization phase of contact hypersensitivity J. Immunol. 161(12),6835-6844(1998).
4. Borgstr?m, P., Hillan, K.J., Sriramarao, P., et al. Complete inhibition of angiogenesis and growth of microtumors by anti-vascular endothelial growth factor neutralizing antibody: Novel concepts of angiostatic therapy from intravital videomicroscopy Cancer Res. 56(17),4032-4039(1996).