PRT062607 Hydrochloride produced dose-dependent anti-inflammatory activity in two rodent models of rheumatoid arthritis. PRT062607 Hydrochloride (15, 30 mg/kg; po; bid; 5 d) causes SYK inhibition in mice and prevents BCR-induced splenomegaly in mice[1].
PRT062607 Hydrochloride (15 mg/kg; po ; bid; 5 d) SYK inhibition in mice prevents Ramos tumor formation in mouse xenograft models[1].
PRT062607 Hydrochloride (10-20 mg/kg; po; bid, ) prevents BCR mediated splenomegaly and significantly inhibited NHL tumor growth in xenograft models[2].
| Animal Model: | anti-IgD Stimulated Mouse Inflammation Model[1] |
| Dosage: | 10 mg/kg, 15 mg/kg, 20 mg/kg |
| Administration: | po; bid for 5 days |
| Result: | Suppressed mouse B-cell activation following stimulation with this anti-IgD.
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| Animal Model: | Ramos Tumor Xenograft Model in NOD/SCID mice[1] |
| Dosage: | 15 mg/kg, 30 mg/kg |
| Administration: | po; bid; terminated when tumor weights began reaching approximately 1.5 mg, at which time tumors were excised and weighed. |
| Result: | Protected mouse from Ramos tumor growth in vivo. |
