卡普瑞林酒石酸盐

Ki: 7 nM (hGHS-R1a)

Capromorelin stimulates GH release in rat pituitary cell cultures with EC ₅₀ of 3 nM.

Dogs receiving capromorelin (30 mg/mL) have food consumption that is significantly greater than dogs treated with placebo. All dogs in the capromorelin group gain weight by 0.52 kg, more than that of placebo group. Capromorelin shows enhanced intestinal absorption in rodent models and exhibits superior pharmacokinetic properties, including high bioavailabilities in two animal species [F(rat)=65%, F(dog)=44%]. Capromorelin stimulates GH release in anesthesized rat model, with ED ₅₀ of 0.05 mg/kg iv.