PYRROLIDINE, 2-(4-FLUOROPHENYL)-1-[(4-METHYLPHENYL)SULFONYL]-, (2S)-
PYRROLIDINE, 2-(4-FLUOROPHENYL)-1-[(4-METHYLPHENYL)SULFONYL]-, (2S)-
![PYRROLIDINE, 2-(4-FLUOROPHENYL)-1-[(4-METHYLPHENYL)SULFONYL]-, (2S)- 结构式](https://img.chemicalbook.com/CAS/20181012/GIF/298690-60-5.gif)
PYRROLIDINE, 2-(4-FLUOROPHENYL)-1-[(4-METHYLPHENYL)SULFONYL]-, (2S)- 性质
| 沸点 | 452.9±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.268±0.06 g/cm3(Predicted) |
| 储存条件 | Store at RT |
| 溶解度 | DMSO：30.0（最大浓度 mg/mL）；93.9（最大浓度 mM） |
| 酸度系数(pKa) | -5.53±0.40(Predicted) |
| 形态 | 粉末 |
| 颜色 | 白色至黄色 |
PYRROLIDINE, 2-(4-FLUOROPHENYL)-1-[(4-METHYLPHENYL)SULFONYL]-, (2S)- 用途与合成方法
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mGluR1a 60.1 nM (EC 50 ) |
In the Purkinje cells of rat cerebellar slices, Ro 67-7476 increases the amplitude of mGluR1 excitatory postsynaptic potentials (EPSCs) evoked by 2,3-dihydroxy-6-nitro-7-sulfamoylbenzoquionxaline, picrotoxin, or AP5. Ro 67-7476 activates ERK1/2 phosphorylation in the absence of exogenously added glutamate (EC 50 =163.3 nM). The EC50 value of full P-ERK1/2 activation for Ro 67-7476 are nearly identical to the EC 50 for calcium mobilization potentiation.Ro 67-7476 increases basal cAMP production approximately by 8%. It potentiated threshold responses to glutamate in the cAMP accumulation assay, with an EC 50 value of 17.7 µM.
PYRROLIDINE, 2-(4-FLUOROPHENYL)-1-[(4-METHYLPHENYL)SULFONYL]-, (2S)- 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | HY-100403 | PYRROLIDINE, 2-(4-FLUOROPHENYL)-1-[(4-METHYLPHENYL)SULFONYL]-, (2S)- | 298690-60-5 | 2mg | 500 |
| 2024-11-08 | HY-100403 | PYRROLIDINE, 2-(4-FLUOROPHENYL)-1-[(4-METHYLPHENYL)SULFONYL]-, (2S)- | 298690-60-5 | 10mM * 1mLin DMSO | 878 |
