oxetan-3-yl-acetic acid ethyl ester

With the structure oxetane, oxetan-3-yl-acetic acid ethyl ester can be used as drug intermediate. In medicinal chemistry, oxetanes have received enormous interest as replacement groups for gem-dimethyl and carbonyl groups with improved physicochemical properties. The small, polar nature of the heterocycle has led to its incorporation as a pendant motif to improve druglike properties.[1]

[1] Oxetanes: Recent Advances in Synthesis, Reactivity, and Medicinal Chemistry. Rev. 2016, 116, 19, 12150–12233. DOI:10.1021/acs.chemrev.6b00274