3'-β-C-乙炔胞苷
![3'-β-C-乙炔胞苷 结构式](https://img.chemicalbook.com/CAS/20180713/GIF/180300-43-0.gif)
3'-β-C-乙炔胞苷 性质
熔点 | 233-235 °C |
---|---|
沸点 | 536.4±60.0 °C(Predicted) |
密度 | 1.61±0.1 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | DMSO:127.5(最大浓度 mg/mL);477.1(最大浓度 mM) DMF:5.0(最大浓度 mg/mL);18.71(最大浓度 mM) PBS (pH 7.2) ):10.0(最大浓度 mg/mL);37.42(最大浓度 mM) |
形态 | 固体 |
酸度系数(pKa) | 11.54±0.70(Predicted) |
颜色 | 白色至黄色 |
3'-β-C-乙炔胞苷 用途与合成方法
nucleoside antimetabolite
The IC 50 values of Ethynylcytidine in the five human tumors with 4, 24 and 72 h exposure range from 0.114 to 1.032 μM, 0.015 to 0.067 μM, and 0.008 to 0.058 μM, respectively. These results suggest that the cytotoxicity of Ethynylcytidine tends to become stronger as the exposure time becomes longer. The differences in IC 50 values between the 24 and 72 h exposure times are not large, and Ethynylcytidine appeares to show sufficiently potent cytotoxicity at the 24 h exposure time in all 5 human tumors. Even at the 4 h exposure time, Ethynylcytidine clearly shows potent cytotoxicity with IC 50 values at submicromolar concentrations in 4 of the 5 human tumors.
In both OCUM-2MD3 and LX-1 xenografts, tumor regression is noted and a very potent antitumor effect with an tumor growth inhibition rate (IR) on day 15 of approximately 90% or even higher is observed at the minimum toxic doses of Ethynylcytidine (TAS-106) on all three administration schedules. In particular, administration of Ethynylcytidine at 6 mg/kg once weekly exhibits a marked tumor shrinking effect with an IR of 98% against the LX-1 tumor. While Ethynylcytidine treatment on an either 3 or 5 times weekly schedule has a potent antitumor effect with an IR of approximately 85%, the IR of Ethynylcytidine once weekly is less than 60% and its antitumor effect is rather weak.
3'-β-C-乙炔胞苷 价格(试剂级)
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024-08-19 | HY-16200 | 1KG | 备注:厂家优势供应 | 180300-43-0 | 5mg | 1400 |
2024-08-19 | HY-16200 | 1KG | 备注:厂家优势供应 | 180300-43-0 | 10mM * 1mLin DMSO | 1540 |