N-[2’-(1H-tetrazol-5-yl)biphenyl-4-yl methyl]-N-Valeryl-(L)-Valine benzyl ester

Benzyl N-valeryl-N-[{2-[1-(triphenylmethyl)-1H-tetrazole-5-yl]]-1,1-biphenyl-4-yl}methyl]-L-valine (330 mg) was dissolved in 6 mL of methanol. The resulting reaction mixture was refluxed under heating for 2 h, and then transferred to room temperature and reacted overnight. After the reaction was completed, the reaction solution was evaporated to dryness under reduced pressure. The residue was then purified by silica gel column chromatography (eluent: cyclohexane/ethyl acetate from 7:3 to 3:7) to obtain valsartan benzyl ester (207 mg, yield 92%).

Figure: Synthetic Route of N-[2’-(1H-tetrazol-5-yl)biphenyl-4-yl methyl]-N-Valeryl-(L)-Valine benzyl ester