2-Chloro-5H-pyrrolo[3,2-d]pyrimidine

63200-54-4

1119280-66-8

2,4-Dichloro-5H-pyrrolo[3,2-d]pyrimidine (134 mg, 0.71 mmol) was used as a feedstock and mixed with NaHCO3 (66 mg, 0.78 mmol) and 10% Pd/C (1.52 mg) in ethanol (4 mL). The reaction mixture was stirred at room temperature for 2.5 h under hydrogen (3 psi) atmosphere. Upon completion of the reaction, the mixture was filtered through a diatomaceous earth plug and the filtrate was evaporated. The residue was purified by fast chromatography to afford 2-chloro-5H-pyrrolo[3,2-d]pyrimidine (90 mg, 88% yield).LC/MS analytical conditions: gradient elution of 20-100% CH3CN with 0.05% HCOOH (aqueous) over 5 min, retention time of 1.58 min, and a molecular ion peak of [M+H]+ of 154 detected.