CCG-2046 is a RGS4 inhibitor with an IC50 of 4.3 μM against RGS4-Gαo interaction signal[1].
Biological Activity
Inhibitor of regulator of G-protein signaling 4 (RGS4). Reduces the RGS4-G α o protein-protein interaction signal.
IC 50
RGS4: 4.3 μM (IC50)
References
[1] Roman DL, et al. Identification of small-molecule inhibitors of RGS4 using a high-throughput flow cytometry protein interaction assay. Mol Pharmacol. 2007 Jan;71(1):169-75. DOI:10.1124/mol.106.028670
