4-Bromoresorcinol

Pink crystalline powder

4-Bromoresorcinol is a reagent for the synthesis of two new series of achiral bent-core mesogens. Also, it is used for the synthesis of a human rhinovirus (HRV) 3C protease inhibitor, pyranonaphthoquinone (-)-thysanone (I).

It is commonly used as an organic reagent and pharmaceutical intermediate.

The Journal of Organic Chemistry, 44, p. 4733, 1979 DOI: 10.1021/jo00393a066

Taking resorcinol as raw material, firstly, resorcinol was added into the reaction vessel, then chloroform was added for dissolution, after dissolution, N-bromosuccinimide dissolved in chloroform obtained N-bromosuccinimide solution was added dropwise into the reaction vessel, N-bromosuccinimide solution dropwise time was 30min, after dropping, the temperature was elevated to 60 , and reaction was carried out for 1h under the condition of this temperature, and the reaction solution was obtained after reaction, and the chloroform was evaporated, and the liquid obtained after evaporation of chloroform was subjected to decompression distillation. Chloroform was evaporated from the obtained reaction solution at atmospheric pressure, and the liquid obtained after evaporation of chloroform was subjected to reduced-pressure distillation, and the 150-160C fraction was collected under a vacuum of 0.098 MPa, and the obtained fraction was cooled down to ambient temperature to obtain 4-bromoresorcinol.